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Инфликсимаб

Также известен как: Инфликсимаб, Ремикейд, Инфликсимаб-биосимиляры
Очень низкий риск (Совместимо)

Биологический препарат для лечения аутоиммунных заболеваний. Считается совместимым с грудным вскармливанием, так как практически не попадает в молоко.

Это справка о веществе, а не назначение. Она не заменяет консультацию врача: решение о приеме и о кормлении принимайте вместе с ним — покажите ему эту карточку.

Дорогая мама, если вам назначили инфликсимаб, знайте: этот препарат имеет очень большую молекулу, которая почти не проникает в грудное молоко. Даже в тех редких случаях, когда препарат обнаруживается, его количество ничтожно мало и клинически незначимо. Более того, при попадании в организм малыша через молоко препарат практически не усваивается из-за особенностей работы кишечника. Многочисленные исследования не выявили негативного влияния на развитие, иммунитет или инфекционную безопасность детей, чьи мамы получали эту терапию. Большинство экспертов в области ревматологии и гастроэнтерологии считают этот препарат безопасным при кормлении грудью. Единственный важный нюанс: обсудите с педиатром график живых вакцин для малыша, так как в некоторых рекомендациях советуют соблюдать осторожность с ними во время терапии мамы.

Фармакокинетика

Пероральная биодоступность ≈ 0 %
Молекулярная масса 144.190 Дальтон
Связывание с белками 97 %
Период полувыведения (T½) 192 - 228 час.
Отношение молоко/плазма (M/P) 0,003 -
Теоретическая доза 0 мг/кг/день
Относительная доза (RID) 0 %
Относит. педиатрическая доза 0 %

Коды АТХ

L04AB02

Источники (64)

Научные работы, на которых основан вердикт по этому веществу. Каждая ссылка ведёт в PubMed — базу Национальной медицинской библиотеки США.

  1. EULAR recommendations for use of antirheumatic drugs in reproduction, pregnancy, and lactation: 2024 update. — Ann Rheum Dis, 2025
  2. Inflammatory Bowel Disease and Breastfeeding: A Narrative Review. — Inflamm Bowel Dis, 2025
  3. British Society for Rheumatology guideline on prescribing drugs in pregnancy and breastfeeding: immunomodulatory anti-rheumatic drugs and corticosteroids. — Rheumatology (Oxford), 2023
  4. European Crohn's and Colitis Guidelines on Sexuality, Fertility, Pregnancy, and Lactation. — J Crohns Colitis, 2023
  5. 2020 American College of Rheumatology Guideline for the Management of Reproductive Health in Rheumatic and Musculoskeletal Diseases. — Arthritis Rheumatol, 2020
  6. British Society of Gastroenterology consensus guidelines on the management of inflammatory bowel disease in adults. — Gut, 2019
  7. A Pharmacological Approach to Managing Inflammatory Bowel Disease During Conception, Pregnancy and Breastfeeding: Biologic and Oral Small Molecule Therapy. — Drugs, 2019
  8. Inflammatory Bowel Disease in Pregnancy Clinical Care Pathway: A Report From the American Gastroenterological Association IBD Parenthood Project Working Group. — Gastroenterology, 2019
  9. Drug Treatment of Rheumatoid Arthritis During Breastfeeding. — Breastfeed Med, 2018
  10. Choosing First-Line Biologic Treatment for Moderate-to-Severe Psoriasis: What Does the Evidence Say? — Am J Clin Dermatol, 2018
  11. Exposure Concentrations of Infants Breastfed by Women Receiving Biologic Therapies for Inflammatory Bowel Diseases and Effects of Breastfeeding on Infections and Development. — Gastroenterology, 2018
  12. The EULAR points to consider for use of antirheumatic drugs before pregnancy, and during pregnancy and lactation. — Ann Rheum Dis, 2016
  13. Pregnancy and the Patient with Inflammatory Bowel Disease: Fertility, Treatment, Delivery, and Complications. — Gastroenterol Clin North Am, 2016
  14. Management of Inflammatory Bowel Disease during Pregnancy and Breastfeeding Varies Widely: A Need for Further Education. — Can J Gastroenterol Hepatol, 2016
  15. BSR and BHPR guideline on prescribing drugs in pregnancy and breastfeeding-Part I: standard and biologic disease modifying anti-rheumatic drugs and corticosteroids. — Rheumatology (Oxford), 2016
  16. The Toronto Consensus Statements for the Management of Inflammatory Bowel Disease in Pregnancy. — Gastroenterology, 2016
  17. The second European evidenced-based consensus on reproduction and pregnancy in inflammatory bowel disease. — J Crohns Colitis, 2015
  18. Care of the Pregnant Patient With Inflammatory Bowel Disease. — Obstet Gynecol, 2015
  19. Are biological drugs safe in pregnancy? — Reumatismo, 2015
  20. [Natural history, complications, safety and pregnancy in inflammatory bowel disease]. — Gastroenterol Hepatol, 2015
  21. Treating Inflammatory Bowel Disease in Pregnancy: The Issues We Face Today. — J Crohns Colitis, 2015
  22. Biologic therapies and pregnancy: the story so far. — Rheumatology (Oxford), 2014
  23. Management of moderate to severe plaque psoriasis in pregnancy and lactation in the era of biologics. — Acta Dermatovenerol Alp Pannonica Adriat, 2014
  24. Safety of dermatologic medications in pregnancy and lactation: Part II. Lactation. — J Am Acad Dermatol, 2014
  25. IBD medications during pregnancy and lactation. — Nat Rev Gastroenterol Hepatol, 2014
  26. Infliximab concentrations in the milk of nursing mothers with inflammatory bowel disease. — J Crohns Colitis, 2014
  27. Rheumatoid arthritis medications and lactation. — Curr Opin Rheumatol, 2014
  28. Lactation and the use of biologic immunosuppressive medications. — Breastfeed Med, 2014
  29. From conception to delivery: managing the pregnant inflammatory bowel disease patient. — World J Gastroenterol, 2014
  30. The use of biologic therapy in pregnancy: a gastroenterologist's perspective. — Curr Opin Rheumatol, 2014
  31. Review article: the management of Crohn's disease and ulcerative colitis during pregnancy and lactation. — Aliment Pharmacol Ther, 2014
  32. Update on pregnancy and breastfeeding in the era of biologics. — Dig Liver Dis, 2013
  33. Placental transfer of anti-tumor necrosis factor agents in pregnant patients with inflammatory bowel disease. — Clin Gastroenterol Hepatol, 2013
  34. Safety of anti-TNF agents during pregnancy and breastfeeding in women with inflammatory bowel disease. — Am J Gastroenterol, 2013
  35. [Anti-TNF therapy in inflammatory bowel diseases during pregnancy and breast-feeding]. — Acta Med Croatica, 2013
  36. Therapeutic infliximab drug level in a child born to a woman with ulcerative colitis treated until gestation week 31. — J Crohns Colitis, 2012
  37. Review of treatment options for psoriasis in pregnant or lactating women: from the Medical Board of the National Psoriasis Foundation. — J Am Acad Dermatol, 2012
  38. Review article: a decision-making algorithm for the management of pregnancy in the inflammatory bowel disease patient. — Aliment Pharmacol Ther, 2012
  39. Pregnancy related issues in inflammatory bowel disease: evidence base and patients' perspective. — World J Gastroenterol, 2012
  40. Infliximab and adalimumab use during breastfeeding. — J Clin Gastroenterol, 2012
  41. Detection of infliximab in breast milk of nursing mothers with inflammatory bowel disease. — J Crohns Colitis, 2011
  42. The London Position Statement of the World Congress of Gastroenterology on Biological Therapy for IBD with the European Crohn's and Colitis Organisation: pregnancy and pediatrics. — Am J Gastroenterol, 2011
  43. [Biologics during pregnancy and breast--feeding]. — Z Rheumatol, 2010
  44. A decade of infliximab: The Austrian evidence based consensus on the safe use of infliximab in inflammatory bowel disease. — J Crohns Colitis, 2010
  45. Inflammatory bowel disease and pregnancy: report of two cases treated with infliximab and a review of the literature. — Eur J Gastroenterol Hepatol, 2010
  46. Safety of immunomodulators and biologics for the treatment of inflammatory bowel disease during pregnancy and breast-feeding. — Inflamm Bowel Dis, 2010
  47. The second European evidence-based Consensus on the diagnosis and management of Crohn's disease: Special situations. — J Crohns Colitis, 2010
  48. Treatment of psoriasis with anti-TNF drugs during pregnancy: case report and review of the literature. — Dermatology, 2010
  49. European evidenced-based consensus on reproduction in inflammatory bowel disease. — J Crohns Colitis, 2010
  50. Management of early aggressive rheumatoid arthritis during pregnancy and lactation. — Expert Opin Pharmacother, 2009
  51. Absence of infliximab in infants and breast milk from nursing mothers receiving therapy for Crohn's disease before and after delivery. — J Clin Gastroenterol, 2009
  52. A 24-year-old pregnant woman with inflammatory bowel disease. — Clin Gastroenterol Hepatol, 2009
  53. Appropriate management of special situations in Crohn's disease (upper gastro-intestinal; extra-intestinal manifestations; drug safety during pregnancy and breastfeeding): Results of a multidisciplinary international expert panel-EPACT II. — J Crohns Colitis, 2009
  54. TNF-alpha blockers in inflammatory bowel diseases: practical consensus recommendations and a user's guide. — Swiss Med Wkly, 2009
  55. Is infliximab safe to use while breastfeeding? — World J Gastroenterol, 2008
  56. [Breastfeeding and drug management in connective tissue and rheumatic diseases]. — Rev Med Interne, 2008
  57. Therapy insight: the use of antirheumatic drugs during nursing. — Nat Clin Pract Rheumatol, 2007
  58. Pregnancy and breastfeeding in patients with Crohn's disease. — Digestion, 2007
  59. Review article: Reproduction in the patient with inflammatory bowel disease. — Aliment Pharmacol Ther, 2007
  60. American gastroenterological association institute technical review on the use of gastrointestinal medications in pregnancy. — Gastroenterology, 2006
  61. Effect of intentional infliximab use throughout pregnancy in inducing and maintaining remission in Crohn's disease. — Dig Liver Dis, 2006
  62. Case report: evidence for transplacental transfer of maternally administered infliximab to the newborn. — Clin Gastroenterol Hepatol, 2006
  63. Anti-inflammatory and immunosuppressive drugs and reproduction. — Arthritis Res Ther, 2006
  64. Intentional infliximab use during pregnancy for induction or maintenance of remission in Crohn's disease. — Aliment Pharmacol Ther, 2005

Источник данных карточки — база e-lactancia.org испанской ассоциации APILAM, опубликованная под лицензией Creative Commons BY-NC-SA 4.0. Перевод на русский язык и оформление — elactancia.ru.

Позаботьтесь о своем здоровье 🌸

Терпеть боль или высокую температуру вредно для организма. Здоровая и спокойная мама — главный залог благополучия ребенка. Ниже приведены три практических правила, как минимизировать риски при приеме препаратов:

1

Правило золотого часа

Принимайте таблетку сразу после кормления. Пик концентрации у большинства препаратов приходится на первые 1–2 часа (в карточке это строка Tmax), и лучше, чтобы он пришелся на промежуток между кормлениями, а не на само прикладывание.

2

Достаточно пить

Пейте столько, сколько просит организм: при температуре и болезни жидкости уходит больше, а от этого зависит и самочувствие, и объем молока. На скорость выведения лекарства питье заметно не влияет — этим занимаются печень и почки.

3

Наблюдение за ребенком

При приеме любых лекарств наблюдайте за реакцией ребенка. Если заметили необычную вялость, сыпь или расстройство пищеварения, временно отложите препарат.